NATURE4 February 2010 Volume 463 Number 7281, pp 587 - 700Visit Nature online to browse the journal.Now available at http://links.ealert.nature.com/ctt?kn=198&m=34602524&r=NDA5MjY2MjAxMgS2&b=2&j=NjY4MTM1NjES1&mt=1&rt=0Please note that you …