Fw: Nature 21 January 2010 Volume 463 Number 7279 pp269-392

21 January 2010 Volume 463 Number 7279, pp 269 - 392

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EDITORIALS

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Climate of suspicion p269
With climate-change sceptics waiting to pounce on any scientific
uncertainties, researchers need a sophisticated strategy for
communication.
doi:10.1038/463269a
http://links.ealert.nature.com/ctt?kn=87&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Ten years of synergy pp269-270
Contributions to and from basic science are the part of synthetic
biology that most deserves celebration.
doi:10.1038/463269b
http://links.ealert.nature.com/ctt?kn=95&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Self-inflicted damage p270
The autocratic actions of an institute's founder could destroy a
centre of excellence for brain research.
doi:10.1038/463270a
http://links.ealert.nature.com/ctt?kn=93&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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RESEARCH HIGHLIGHTS

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Microbiology: Life in the lost city p272
doi:10.1038/463272a
http://links.ealert.nature.com/ctt?kn=60&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Geophysics: Synthetic sky light p272
doi:10.1038/463272b
http://links.ealert.nature.com/ctt?kn=65&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Chemistry: Chase acid, solve maze p272
doi:10.1038/463272c
http://links.ealert.nature.com/ctt?kn=72&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Astrophysics: Dusty galaxy p272
doi:10.1038/463272d
http://links.ealert.nature.com/ctt?kn=77&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Evolutionary biology: How girls go solo p272
doi:10.1038/463272e
http://links.ealert.nature.com/ctt?kn=120&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Biochemistry: Designer label pp272-273
doi:10.1038/463272f
http://links.ealert.nature.com/ctt?kn=91&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Ecology: Asocial invaders p273
doi:10.1038/463273a
http://links.ealert.nature.com/ctt?kn=103&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Geoscience: Blowin' in the wind p273
doi:10.1038/463273b
http://links.ealert.nature.com/ctt?kn=97&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Evolutionary biology: Sperm signals p273
doi:10.1038/463273c
http://links.ealert.nature.com/ctt?kn=116&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Neuropharmacology: Beating depression p273
doi:10.1038/463273d
http://links.ealert.nature.com/ctt?kn=110&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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JOURNAL CLUB

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Journal club p273
Mark J. Schnitzer
doi:10.1038/463273e
http://links.ealert.nature.com/ctt?kn=35&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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NEWS

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News briefing: 21 January 2010 pp274-275
The week in science.
doi:10.1038/463274a
http://links.ealert.nature.com/ctt?kn=146&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Glacier estimate is on thin ice pp276-277
IPCC may modify its Himalayan melting forecasts.
Quirin Schiermeier
doi:10.1038/463276a
http://links.ealert.nature.com/ctt?kn=259&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Geologists to evaluate future Haiti risks pp276-277
Hunt for survey markers may reveal crucial data.
Rex Dalton
doi:10.1038/463276b
http://links.ealert.nature.com/ctt?kn=260&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Genomics boosts brain-cancer work pp278
Molecular findings start to open up avenues of diagnosis
and treatment.
Erika Check Hayden
doi:10.1038/463278a
http://links.ealert.nature.com/ctt?kn=252&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Iranian academics fear more killings p279
Concern grows in the wake of particle physicist's death.
Declan Butler
doi:10.1038/463279a
http://links.ealert.nature.com/ctt?kn=150&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

The scientific diplomat p281
AAAS president Peter Agre talks to Nature about his recent
visits to Cuba and North Korea.
David Cyranoski
doi:10.1038/463281a
http://links.ealert.nature.com/ctt?kn=247&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

'Big science' spurs collaborative trend p282
Complicated projects mean that science is becoming more globalized.
Eric Hand
doi:10.1038/463282a
http://links.ealert.nature.com/ctt?kn=291&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Bulgarian science reform attacked p283
Researchers say law wouldn't fix nation's higher-education system.
Alison Abbott
doi:10.1038/463283a
http://links.ealert.nature.com/ctt?kn=289&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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NEWS FEATURES

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Climate: The real holes in climate science pp284-287
Like any other field, research on climate change has some fundamental
gaps, although not the ones typically claimed by sceptics. Quirin
Schiermeier takes a hard look at some of the biggest problem areas.
Quirin Schiermeier
doi:10.1038/463284a
http://links.ealert.nature.com/ctt?kn=255&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Bioengineering: Five hard truths for synthetic biology pp288-290
Can engineering approaches tame the complexity of living systems?
Roberta Kwok explores five challenges for the field and how they
might be resolved.
Roberta Kwok
doi:10.1038/463288a
http://links.ealert.nature.com/ctt?kn=267&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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COLUMN

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World view: Wild goose chase pp291-291
Quantitative research assessment is a bad idea whose time has come,
argues Colin Macilwain.
doi:10.1038/463291a
http://links.ealert.nature.com/ctt?kn=273&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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CORRESPONDENCE

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Advocacy for carbon capture and storage could arouse distrust p293
Heleen de Coninck
doi:10.1038/463293a
http://links.ealert.nature.com/ctt?kn=31&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Activists should be consulted in animal testing decisions p293
Fern Wickson
doi:10.1038/463293b
http://links.ealert.nature.com/ctt?kn=33&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Conservation work is incomplete without cryptic biodiversity p293
Genoveva F. Esteban and Bland J. Finlay
doi:10.1038/463293c
http://links.ealert.nature.com/ctt?kn=27&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Geothermal energy stuck between a rock and a hot place p293
Shaopeng Huang and Jiaqi Liu
doi:10.1038/463293d
http://links.ealert.nature.com/ctt?kn=29&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Correction p293
doi:10.1038/463293e
http://links.ealert.nature.com/ctt?kn=50&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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OPINION

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A route to more tractable expert advice pp294-295
There are mathematically advanced ways to weigh and pool scientific
advice. They should be used more to quantify uncertainty and improve
decision-making, says Willy Aspinall.
Willy Aspinall
doi:10.1038/463294a
http://links.ealert.nature.com/ctt?kn=48&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Fixing the communications failure pp296-297
People's grasp of scientific debates can improve if communicators
build on the fact that cultural values influence what and whom we
believe, says Dan Kahan.
doi:10.1038/463296a
http://links.ealert.nature.com/ctt?kn=46&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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BOOKS AND ARTS

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Vision of a personal genomics future pp298-299
The director of the US National Institutes of Health, Francis Collins,
calls for a revolution in personalized medicine. Such advances should
be shared beyond the developed world, says Abdallah S. Daar.
Abdallah S. Daar reviews The Language of Life: DNA and the Revolution
in Personalized Medicine by Francis S. Collins
doi:10.1038/463298a
http://links.ealert.nature.com/ctt?kn=44&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

The bootleggers' legacy p299
Laura Spinney reviews The Poisoner's Handbook: Murder and the Birth
of Forensic Medicine in Jazz Age New York by Deborah Blum
doi:10.1038/463299a
http://links.ealert.nature.com/ctt?kn=42&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Turin's criminology museum p300
Alison Abbott reviews Museum of Criminal Anthropology 'Cesare Lombroso'
doi:10.1038/463300a
http://links.ealert.nature.com/ctt?kn=8&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Culture dish: Doom-laden Sundance p300
Jascha Hoffman
doi:10.1038/463300b
http://links.ealert.nature.com/ctt?kn=10&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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NEWS AND VIEWS

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Synthetic biology: Synchronized bacterial clocks pp301-302
By synchronizing clocks, humans make more efficient use of their
time and orchestrate their activities in different places. Bacteria
have now been engineered that similarly coordinate their molecular
timepieces.
Martin Fussenegger
doi:10.1038/463301a
http://links.ealert.nature.com/ctt?kn=2&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Materials science: Membrane magic pp302-303
The use of magnetic fields to assemble particles into membranes
provides a powerful tool for exploring the physics of self-assembly
and a practical method for synthesizing functional materials.
Jack F. Douglas
doi:10.1038/463302a
http://links.ealert.nature.com/ctt?kn=5&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Genetics: Decoding a national treasure pp303-304
The giant-panda genome is the first reported de novo assembly of a
large mammalian genome achieved using next-generation sequencing
methods. The feat reflects a trend towards ever-decreasing
genome-sequencing costs.
Kim C. Worley and Richard A. Gibbs
doi:10.1038/463303a
http://links.ealert.nature.com/ctt?kn=7&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Asteroids: Stripped on passing by Earth pp305-306
Asteroids are weakly bound piles of rubble, and if one comes close
to Earth, tides can cause the object to undergo landslides and
structural rearrangement. The outcome of this encounter is a body
with meteorite-like colours.
Clark R. Chapman
doi:10.1038/463305a
http://links.ealert.nature.com/ctt?kn=25&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Evolutionary biology: New take on the Red Queen pp306-307
Biologists have assumed that natural selection shapes larger patterns
of evolution through interactions such as competition and predation.
These patterns may instead be determined by rare, stochastic speciation.
Michael J. Benton
doi:10.1038/463306a
http://links.ealert.nature.com/ctt?kn=17&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Atmospheric chemistry: More ozone over North America pp307-308
Springtime ozone levels in the lower atmosphere over western North
America are rising. The source of this pollution may be Asia, a
finding that reaffirms the need for international air-quality control.
Kathy Law
doi:10.1038/463307a
http://links.ealert.nature.com/ctt?kn=16&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Cell biology: How cilia beat pp308-309
Physics provides new approaches to difficult biological problems:
a plausible mathematical model of how cilia and flagella beat has
been formulated, but it needs to be subjected to rigorous
experimental tests.
T. J. Mitchison and H. M. Mitchison
doi:10.1038/463308a
http://links.ealert.nature.com/ctt?kn=293&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Correction p309
doi:10.1038/463309a
http://links.ealert.nature.com/ctt?kn=304&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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BRIEF COMMUNICATIONS ARISING

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Essentiality of FASII pathway for Staphylococcus aureus pE3
Wendy Balemans et al.
doi:10.1038/nature08667
Abstract: http://links.ealert.nature.com/ctt?kn=278&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=313&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Brinster et al. reply pE4
Sophie Brinster et al.
doi:10.1038/nature08668
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=308&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

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ARTICLES

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The sequence and de novo assembly of the giant panda genome pp311-317
Here, a draft sequence of the giant panda genome is assembled using
next-generation sequencing technology alone. Genome analysis reveals
a low divergence rate in comparison with dog and human genomes and
insights into panda-specific traits; for example, the giant panda's
bamboo diet may be more dependent on its gut microbiome than its own
genetic composition.
Ruiqiang Li et al.
doi:10.1038/nature08696
Abstract: http://links.ealert.nature.com/ctt?kn=282&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=263&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

The transcriptional network for mesenchymal transformation of brain
tumours pp318-325
A mesenchymal phenotype is the hallmark of tumour aggressiveness in
human malignant glioma, but the regulatory programs responsible for
implementing the associated molecular signature are largely unknown.
Reverse-engineering and an unbiased interrogation of a glioma-specific
regulatory network now reveal the transcription factors that activate
expression of mesenchymal genes in malignant glioma.
Maria Stella Carro et al.
doi:10.1038/nature08712
Abstract: http://links.ealert.nature.com/ctt?kn=283&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=277&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

A synchronized quorum of genetic clocks pp326-330
A defining focus of synthetic biology is the engineering of genetic
circuits with predictive functionality in living cells. Here, a decade
after the first synthesized genetic toggle switch and oscillator, an
engineered gene network with global intercellular coupling is designed
that is capable of generating synchronized oscillations in a growing
population of cells.
Tal Danino, Octavio Mondragon-Palomino, Lev Tsimring and Jeff Hasty
doi:10.1038/nature08753
Abstract: http://links.ealert.nature.com/ctt?kn=297&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=284&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

                                          • -

LETTERS

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Earth encounters as the origin of fresh surfaces on near-Earth
asteroids pp331-334
Telescopic measurements of asteroids' colours rarely match laboratory
reflectance spectra of meteorites owing to a 'space weathering'
process that rapidly reddens asteroid surfaces. 'Unweathered'
asteroids, however, with spectra matching ordinary chondrite meteorites,
are seen only among small bodies with orbits that cross inside the
orbits of Mars and Earth. Such unweathered asteroids are now shown to
have experienced orbital intersections closer than the Earth-Moon
distance within the past half-million years.
Richard P. Binzel et al.
doi:10.1038/nature08709
Abstract: http://links.ealert.nature.com/ctt?kn=292&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=235&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Strong crystal size effect on deformation twinning pp335-338
Although deformation twinning in crystals controls the mechanical
behaviour of many materials, its size-dependence has not been
explored. Using micro-compression and in situ nano-compression
experiments, the stress required for deformation twinning is now
found to increase drastically with decreasing sample size of a
titanium alloy single crystal, until the sample size is reduced to
one micrometre; below this point, deformation twinning is replaced
by dislocation plasticity.
Qian Yu et al.
doi:10.1038/nature08692
Abstract: http://links.ealert.nature.com/ctt?kn=294&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=231&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

High-water-content mouldable hydrogels by mixing clay and a dendritic
molecular binder pp339-343
In the search to reduce our dependency on fossil-fuel energy, new
plastic materials that are less dependent on petroleum are being
developed, with water-based gels -- hydrogels -- representing one
possible solution. Here, a mixture of water, 3% clay and a tiny
amount of a special organic binder is shown to form a transparent
hydrogel that can be moulded into shape-persistent, free-standing
objects and that rapidly and completely self-heals when damaged.
Qigang Wang et al.
doi:10.1038/nature08693
Abstract: http://links.ealert.nature.com/ctt?kn=303&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=244&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Increasing springtime ozone mixing ratios in the free troposphere over
western North America pp344-348
High concentrations of ozone in the troposphere are toxic and act as a
greenhouse gas. Anthropogenic emissions of ozone precursors have caused
widespread increases in ozone concentrations since the late 1800s, with
the fastest-growing ozone precursor emissions currently coming out of
east Asia. Much of the springtime east Asian pollution is exported
towards western North America; a strong increase in springtime ozone
mixing ratios is now found in the free troposphere over this region.
O. R. Cooper et al.
doi:10.1038/nature08708
Abstract: http://links.ealert.nature.com/ctt?kn=305&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Phylogenies reveal new interpretation of speciation and the Red Queen
pp349-352
The Red Queen metaphor has species accumulating small changes to keep
up with a continually changing environment, with speciation occurring
at a constant rate. This constant-rate claim is now tested against four
competing models, using 101 phylogenies of animal, plant and fungal
taxa. The results provide a new interpretation of the Red Queen; a view
linking speciation to rare stochastic events that cause reproductive
isolation.
Chris Venditti, Andrew Meade and Mark Pagel
doi:10.1038/nature08630
Abstract: http://links.ealert.nature.com/ctt?kn=298&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Mutational robustness can facilitate adaptation pp353-355
If robustness is the opposite of evolvability, we might expect that a
robust population would have difficulty adapting to environmental change;
however, some studies have suggested that genetic robustness facilitates
adaptation. Here, using a general population genetics model, mutational
robustness is found to either impede or facilitate adaptation depending
on the population size, the mutation rate and the structure of the
fitness landscape.
Jeremy A. Draghi, Todd L. Parsons, Gunter P. Wagner and Joshua B. Plotkin
doi:10.1038/nature08694
Abstract: http://links.ealert.nature.com/ctt?kn=301&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Prejudice and truth about the effect of testosterone on human bargaining
behaviour pp356-359
Evidence from animal studies shows that testosterone can induce
aggressive behaviour, but whether this extrapolates to humans is an
area of debate. The sublingual administration of a single dose of
testosterone in women is now shown to cause a substantial increase
in fair bargaining behaviour, although subjects who believed they
received testosterone behaved much more unfairly than those who
thought they received a placebo.
C. Eisenegger et al.
doi:10.1038/nature08711
Abstract: http://links.ealert.nature.com/ctt?kn=310&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Systematic sequencing of renal carcinoma reveals inactivation of
histone modifying genes pp360-363
Clear cell renal carcinoma, the most common form of adult kidney
cancer, is often characterized by the presence of inactivating
mutations in the VHL gene. A large survey for somatic mutations now
identifies inactivating mutations in two genes encoding enzymes
involved in histone modification, highlighting the role of mutations
in components of the chromatin modification machinery in human cancer.
Gillian L. Dalgliesh et al.
doi:10.1038/nature08672
Abstract: http://links.ealert.nature.com/ctt?kn=312&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA
splicing in cancer pp364-368
Expression of the embryonic M2 isoform of pyruvate kinase (PKM2) by
tumour cells promotes aerobic glycolysis, whereas the normal adult
isoform, PKM1, promotes oxidative phosphorylation. Expression of
these isoforms is regulated by alternative splicing; here, aberrant
expression of three heterogeneous nuclear ribonucleoprotein splicing
factors, which are themselves regulated by the c-Myc oncogene, is
shown to be responsible for the M1 to M2 switch in cancer.
Charles J. David et al.
doi:10.1038/nature08697
Abstract: http://links.ealert.nature.com/ctt?kn=307&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=176&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

FOXO-dependent regulation of innate immune homeostasis pp369-373
Antimicrobial peptides (AMPs) are an important class of immune
effector molecules which fight pathogen infections. AMP induction in
Drosophila is regulated through the activation of the Toll and immune
deficiency pathways; it is now shown that AMP activation can be
achieved independently of these pathways by the transcription factor
FOXO. In non-infected animals, AMP genes are activated in response to
nuclear FOXO activity when induced by starvation.
Thomas Becker et al.
doi:10.1038/nature08698
Abstract: http://links.ealert.nature.com/ctt?kn=217&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=169&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Transcriptional role of cyclin D1 in development revealed by a
genetic-proteomic screen pp374-378
Although cyclin D1 is frequently overexpressed in human cancers, the
full range of its functions in normal development and oncogenesis is
unclear. Here, tagged cyclin D1 knock-in mouse strains are developed
to allow a search for cyclin D1-binding proteins in different mouse
organs using high-throughput mass spectrometry. The results show that,
in addition to its established cell cycle roles, cyclin D1 has an in
vivo transcriptional function in mouse development.
Frederic Bienvenu et al.
doi:10.1038/nature08684
Abstract: http://links.ealert.nature.com/ctt?kn=218&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=173&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Mechanism of folding chamber closure in a group II chaperonin pp379-383
Group II chaperonins are present in eukaryotes and archaea and are
essential mediators of cellular protein folding. This process is
critically dependent on the closure of a built-in lid, which is
triggered by ATP hydrolysis, but the structural rearrangements and
molecular events leading to lid closure are unknown. Using cryo-electron
microscopy, the structures of an archaeal group II chaperonin in the
open and closed states are now reported, providing details of this
mechanism.
Junjie Zhang et al.
doi:10.1038/nature08701
Abstract: http://links.ealert.nature.com/ctt?kn=219&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=194&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

                                          • -

ERRATUM

                                          • -

Direct inhibition of the NOTCH transcription factor complex p384
Raymond E. Moellering et al.
doi:10.1038/nature08660
http://links.ealert.nature.com/ctt?kn=191&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Thickness and Clapeyron slope of the post-perovskite boundary p384
Krystle Catalli, Sang-Heon Shim and Vitali Prakapenka
doi:10.1038/nature08770
http://links.ealert.nature.com/ctt?kn=197&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

                                          • -

CORRIGENDUM

                                          • -

Cyclical DNA methylation of a transcriptionally active promoter p384
Raphael Metivier et al.
doi:10.1038/nature08661
http://links.ealert.nature.com/ctt?kn=147&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

FGF signalling during embryo development regulates cilia length in
diverse epithelia p384
Judith M. Neugebauer et al.
doi:10.1038/nature08771
http://links.ealert.nature.com/ctt?kn=149&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

                                          • -

NATUREJOBS

                                          • -

Careers Q&A
Q&A p387
Jon Gluyas of Durham University, UK, is the country's first professor
of carbon capture and storage and geoenergy.
Virginia Gewin
doi:10.1038/nj7279-387a
http://links.ealert.nature.com/ctt?kn=127&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

In Brief
Charles River downsizes p387
Downturn forces closure of Charles River Labs division.
doi:10.1038/nj7279-387b
http://links.ealert.nature.com/ctt?kn=99&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

In Brief
Small rise for US postdocs p387
NIH stipend increase not enough, says US National Postdoctoral
Association.
doi:10.1038/nj7279-387c
http://links.ealert.nature.com/ctt?kn=117&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

In Brief
Biotech ends on a high p387
Biotech firms raise much more money in 2009, buoyed by big pharma
partnerships
doi:10.1038/nj7279-387d
http://links.ealert.nature.com/ctt?kn=131&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Careers and Recruitment
Tricky terrains p388
The drug and biotech industries are not always easy to break into.
Developing a diverse skill set could be the key to success,
Karen Kaplan reports.
doi:10.1038/nj7279-388a
http://links.ealert.nature.com/ctt?kn=129&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

                                          • -

FUTURES

                                          • -

Strange machine p392
A fair exchange?
Taik Hobson
doi:10.1038/463392a
http://links.ealert.nature.com/ctt?kn=142&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

                                          • -

Advance Online Publication

                                          • -

14 January 2010
JARID2 regulates binding of the Polycomb repressive complex 2 to
target genes in ES cells
near-final version
Diego Pasini et al.
doi:10.1038/nature08788
Abstract: http://links.ealert.nature.com/ctt?kn=220&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

20 January 2010
Evidence for grid cells in a human memory network
Christian F. Doeller, Caswell Barry and Neil Burgess
doi:10.1038/nature08704
Abstract: http://links.ealert.nature.com/ctt?kn=213&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=138&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Mammalian biodiversity on Madagascar controlled by ocean currents
Jason R. Ali and Matthew Huber
doi:10.1038/nature08706
Abstract: http://links.ealert.nature.com/ctt?kn=214&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=162&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Competition drives cooperation among closely related sperm of
deer mice
Heidi S. Fisher and Hopi E. Hoekstra
doi:10.1038/nature08736
Abstract: http://links.ealert.nature.com/ctt?kn=215&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Mechanism of substrate recognition and transport by an amino acid
antiporter
Xiang Gao et al.
doi:10.1038/nature08741
Abstract: http://links.ealert.nature.com/ctt?kn=216&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=155&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

17 January 2010
DNMT1 maintains progenitor function in self-renewing somatic tissue
George L. Sen et al.
doi:10.1038/nature08683
Abstract: http://links.ealert.nature.com/ctt?kn=222&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=264&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0

Genome-wide RNAi screen identifies human host factors crucial for
influenza virus replication
Alexander Karlas et al.
doi:10.1038/nature08760
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=272&m=34566576&r=NDA5MjY2MjAxMgS2&b=2&j=NjQ2MjUzOTcS1&mt=1&rt=0